RAF Typhoon FGR4s have joined forces with France's air force in a combined operation against an subterranean weapons facility in Syrian territory operated by the Islamic State group (IS), according to the British defence ministry.
The site, pinpointed through intelligence, was thought to be storing arms and explosives, the release indicated, and was located in hills just above the ancient city of Palmyra in Syria's central region.
"The RAF jets used Paveway IV guided bombs to strike a several entry passages down to the facility... initial indications are that the strike was effective," the ministry announced.
There was no sign of any civilian casualties in the strike conducted Saturday night and each participating jet returned to base without incident, the MoD added.
The Typhoon FGR4s were assisted by a Voyager refuelling tanker.
IS - also known as Daesh - imposed militant control over significant areas in both Syria and Iraq prior to its 2019 collapse.
"This action shows our UK leadership, and determination to operate in unison with our partners, to stamp out any resurgence of IS and their violent and radical beliefs in the region," UK Defence Secretary John Healey said.
British military aircraft have carried out patrols over Syria to "forestall any attempted comeback" of the group following its military defeat at the battle of Baghuz in the year 2019, the ministry said.
"I want to thank all the members of our armed forces who took part in this strike for their skill and their valour," he added. "They were among thousands of British troops stationed over the holidays. This mission, to eliminate militants who endanger our security, demonstrates how our armed forces are ready to step up, throughout the year, keeping Britain secure domestically and influential overseas."
Last December, the United States armed forces executed what it described as a "large-scale strike" on Daesh sites in Syria, following an attack claimed the lives of two US troops and a local interpreter in Palmyra.
The UN reports Daesh still has between 5,000 and 7,000 combatants in both countries.